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Haematological adverse effects associated with linezolid in patients with drug-resistant tuberculosis: an exploratory study

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dc.date.accessioned 2019-08-19T12:22:41Z
dc.date.available 2019-08-19T12:22:41Z
dc.date.issued 2019-05-30 en
dc.identifier.uri http://hdl.handle.net/20.500.11910/13965
dc.description.abstract The objectives of this study were to identify the incidence of haematological adverse effects associated with linezolid. Medical records of 27 hospitalised patients in South Africa with drug-resistant tuberculosis (DR-TB) and prescribed linezolid therapy were retrospectively reviewed. Approximately a quarter (n = 7) of patients experienced haematological adverse effects. These included anaemia (14.8%; n = 4), low haemoglobin (7.4%; n = 2) and macrocytosis (3.7%; n = 1). All patients who exhibited haematological adverse effects were living with HIV. The haematological effects of linezolid manifested in patients who were suffering from co-morbid HIV. Haematological monitoring should be done monthly in order to detect adverse effects timeously and intervene as appropriate. en
dc.format.medium Print en
dc.subject DRUG RESISTANCE en
dc.subject TUBERCULOSIS en
dc.title Haematological adverse effects associated with linezolid in patients with drug-resistant tuberculosis: an exploratory study en
dc.type Journal Article en
dc.description.version Y en
dc.ProjectNumber N/A en
dc.Volume May en
dc.BudgetYear 2019/20 en
dc.ResearchGroup Social Aspects of Public Health en
dc.SourceTitle International Journal of Pharmacy Practice en
dc.ArchiveNumber 10872 en
dc.PageNumber Online en
dc.outputnumber 9949 en
dc.bibliographictitle Letswee, G., Kamau, H., Gaida, R. & Trutor, I. (2019) Haematological adverse effects associated with linezolid in patients with drug-resistant tuberculosis: an exploratory study. <i>International Journal of Pharmacy Practice</i>. May:Online. en
dc.publicationyear 2019 en
dc.contributor.author1 Letswee, G. en
dc.contributor.author2 Kamau, H. en
dc.contributor.author3 Gaida, R. en
dc.contributor.author4 Trutor, I. en


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