The contribution of maternal HIV seroconversion during late pregnancy and breastfeeding to mother-to-child transmission of HIV

Show simple item record

dc.date.accessioned 2012-03-12 en
dc.date.accessioned 2022-08-17T18:30:28Z
dc.date.available 2022-08-17T18:30:28Z
dc.date.issued 2015-08-25 en
dc.identifier.uri http://hdl.handle.net/20.500.11910/3497
dc.description.abstract The prevention of mother-to-child transmission (PMTCT) of HIV has been focused mainly on women who are HIV positive at their first antenatal visit, but there is uncertainty regarding the contribution to overall transmission from mothers who seroconvert after their first antenatal visit and before weaning. A mathematical model was developed to simulate changes in mother-to-child transmission of HIV over time, in South Africa. The model allows for changes in infant feeding practices as infants age, temporal changes in the provision of antiretroviral prophylaxis and counseling on infant feeding, as well as temporal changes in maternal HIV prevalence and incidence. The proportion of mother-to-child transmission (MTCT) from mothers who seroconverted after their first antenatal visit was 26% [95% confidence interval (CI): 22% to 30%] in 2008, or 15,000 of 57,000 infections. It is estimated that by 2014, total MTCT will reduce to 39,000 per annum, and transmission from mothers seroconverting after their first antenatal visit will reduce to 13,000 per annum, accounting for 34% (95% CI: 29% to 39%) of MTCT. If maternal HIV incidence during late pregnancy and breastfeeding were reduced by 50% after 2010, and HIV screening were repeated in late pregnancy and at 6-week immunization visits after 2010, the average annual number of MTCT cases over the 2010-2015 period would reduce by 28% (95% CI: 25% to 31%), from 39,000 to 28,000 per annum. Maternal seroconversion during late pregnancy and breastfeeding contributes significantly to the pediatric HIV burden and needs greater attention in the planning of prevention of MTCT programs. en
dc.format.medium Print en
dc.subject HIV/AIDS en
dc.subject PREVENTION OF MOTHER TO CHILD TRANSMISSION (PMTCT) PROGRAMME en
dc.subject VERTICAL TRANSMISSION STUDY en
dc.title The contribution of maternal HIV seroconversion during late pregnancy and breastfeeding to mother-to-child transmission of HIV en
dc.type Journal Article en
dc.description.version Y en
dc.ProjectNumber N/A en
dc.Volume 59(4) en
dc.BudgetYear 2011/12 en
dc.ResearchGroup HIV/AIDS, STIs and TB en
dc.SourceTitle JAIDS - Journal of Acquired Immune Deficiency Syndromes en
dc.ArchiveNumber 7133 en
dc.PageNumber 417-425 en
dc.outputnumber 5780 en
dc.bibliographictitle Johnson, L.F., Stinson, K., Newell, M-L., Bland, R.M., Moultrie, H., Davies, M-A., Rehle, T.M., Dorrington, R.E. & Sherman, G.G. (2012) The contribution of maternal HIV seroconversion during late pregnancy and breastfeeding to mother-to-child transmission of HIV. JAIDS - Journal of Acquired Immune Deficiency Syndromes. 59(4):417-425. http://hdl.handle.net/20.500.11910/3497 en
dc.publicationyear 2012 en
dc.contributor.author1 Johnson, L.F. en
dc.contributor.author2 Stinson, K. en
dc.contributor.author3 Newell, M-L. en
dc.contributor.author4 Bland, R.M. en
dc.contributor.author5 Moultrie, H. en
dc.contributor.author6 Davies, M-A. en
dc.contributor.author7 Rehle, T.M. en
dc.contributor.author8 Dorrington, R.E. en
dc.contributor.author9 Sherman, G.G. en


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record