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Accuracy of serological assays for detection of recent infection with HIV and estimation of population incidence: a systematic review

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dc.date.accessioned 2010-01-18 en
dc.date.accessioned 2016-12-04T18:38:09Z
dc.date.available 2016-12-04T18:38:09Z
dc.date.issued 2015-08-25 en
dc.identifier.uri http://hdl.handle.net/20.500.11910/4417
dc.description.abstract We systematically reviewed the accuracy of serological tests for recent infections with HIV that have become widely used for measuring population patterns incidence of HIV. Across 13 different assays, sensitivity to detect recent infections ranged from 42-100% (median 89%). Specificity for detecting established infections was between 49?5% and 100% (median 86?8%) and was higher for infections of durations longer than 1 year (median 98%, range 31?5-100?0). For four different assays, comparisons were made between assay-derived population incidence estimates and a reference incidence estimate. The median percentage difference between the assay-derived incidence and reference incidence was 26?0%. Serological assays have reasonable sensitivity for the detection of recent infection with HIV, but are vulnerable to misclassifying established infections as recent potentially leading to biases in incidence estimates. This conclusion is highly qualified by the apparent absence of a standardised approach to assay evaluation. There is an urgent need for an internationally agreed framework for evaluating and comparing these tests. en
dc.format.medium Print en
dc.subject HIV/AIDS en
dc.subject HIV TESTING AND COUNSELLING (HTC) en
dc.subject STATISTICS en
dc.title Accuracy of serological assays for detection of recent infection with HIV and estimation of population incidence: a systematic review en
dc.type Journal Article en
dc.description.version Y en
dc.Volume 9 en
dc.BudgetYear 2009/10 en
dc.ResearchGroup Social Aspects of HIV/AIDS and Health en
dc.SourceTitle The Lancet en
dc.ArchiveNumber 6190 en
dc.PageNumber 747-759 en
dc.outputnumber 4839 en
dc.bibliographictitle Guy, R., Gold, J., Calleja, J.M.G., Kim, A.A., Parekh, B., Busch, M., Rehle, T., Hargrove, J., Remis, R.S. & Kaldor, J.M. (2009) Accuracy of serological assays for detection of recent infection with HIV and estimation of population incidence: a systematic review. <i>The Lancet</i>. 9:747-759. en
dc.publicationyear 2009 en
dc.contributor.author1 Guy, R. en
dc.contributor.author2 Gold, J. en
dc.contributor.author3 Calleja, J.M.G. en
dc.contributor.author4 Kim, A.A. en
dc.contributor.author5 Parekh, B. en
dc.contributor.author6 Busch, M. en
dc.contributor.author7 Rehle, T. en
dc.contributor.author8 Hargrove, J. en
dc.contributor.author9 Remis, R.S. en
dc.contributor.author10 Kaldor, J.M. en


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