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Community-based antiretroviral therapy versus standard clinic-based services for HIV in South Africa and Uganda (DO ART): a randomised trial

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dc.date.accessioned 2020-11-23T13:15:08Z
dc.date.available 2020-11-23T13:15:08Z
dc.date.issued 2020-10-15 en
dc.identifier.uri http://hdl.handle.net/20.500.11910/15456
dc.description.abstract Community-based delivery of antiretroviral therapy (ART) for HIV, including ART initiation, clinical and laboratory monitoring, and refills, could reduce barriers to treatment and improve viral suppression, reducing the gap in access to care for individuals who have detectable HIV viral load, including men who are less likely than women to be virally suppressed. We aimed to test the effect of community-based ART delivery on viral suppression among people living with HIV not on ART. We did a household-randomised, unblinded trial (DO ART) of delivery of ART in the community compared with the clinic in rural and peri-urban settings in KwaZulu-Natal, South Africa and the Sheema District, Uganda. After community-based HIV testing, people living with HIV were randomly assigned (1:1:1) with mobile phone software to community-based ART initiation with quarterly monitoring and ART refills through mobile vans; ART initiation at the clinic followed by mobile van monitoring and refills (hybrid approach); or standard clinic ART initiation and refills. The primary outcome was HIV viral suppression at 12 months. If the difference in viral suppression was not superior between study groups, an a-priori test for non-inferiority was done to test for a relative risk (RR) of more than 0-5. The cost per person virally suppressed was a co-primary outcome of the study. en
dc.format.medium Print en
dc.subject HIV/AIDS en
dc.subject ANTIRETROVIRAL THERAPY (ART) en
dc.subject UGANDA en
dc.subject SOUTH AFRICA en
dc.title Community-based antiretroviral therapy versus standard clinic-based services for HIV in South Africa and Uganda (DO ART): a randomised trial en
dc.type Journal Article en
dc.description.version Y en
dc.ProjectNumber N/A en
dc.Volume 8 en
dc.BudgetYear 2020/21 en
dc.ResearchGroup Developmental, Capable and Ethical State en
dc.ResearchGroup Human and Social Capabilities en
dc.ResearchGroup Impact Centre en
dc.SourceTitle Lancet Global Health en
dc.ArchiveNumber 11588 en
dc.PageNumber Online en
dc.outputnumber 10732 en
dc.bibliographictitle Barnabas, R.V., Szpiro, A.A., Van Rooyen, H., Asiimwe, S., Pillay, D., Ware, N.C., Schaafsma, T.T., Krows, M.L., Van Heerden, A., Joseph, P., Shahmanesh, M., Wyatt, M.A., Sausi, K., Turyamureeba, B., Sithole, N., Morrison, S., Shapiro, A.E., Roberts, D.A., Thomas, K.K., Koole, O., Bershteyn, A., Ehrenkranz, P., Baeten, J.M. & Celum, C. (2020) Community-based antiretroviral therapy versus standard clinic-based services for HIV in South Africa and Uganda (DO ART): a randomised trial . <i>Lancet Global Health</i>. 8:Online. http://hdl.handle.net/20.500.11910/15456 en
dc.publicationyear 2020 en
dc.contributor.author1 Barnabas, R.V. en
dc.contributor.author2 Szpiro, A.A. en
dc.contributor.author3 Van Rooyen, H. en
dc.contributor.author4 Asiimwe, S. en
dc.contributor.author5 Pillay, D. en
dc.contributor.author6 Ware, N.C. en
dc.contributor.author7 Schaafsma, T.T. en
dc.contributor.author8 Krows, M.L. en
dc.contributor.author9 Van Heerden, A. en
dc.contributor.author10 Joseph, P. en
dc.contributor.author11 Shahmanesh, M. en
dc.contributor.author12 Wyatt, M.A. en
dc.contributor.author13 Sausi, K. en
dc.contributor.author14 Turyamureeba, B. en
dc.contributor.author15 Sithole, N. en
dc.contributor.author16 Morrison, S. en
dc.contributor.author17 Shapiro, A.E. en
dc.contributor.author18 Roberts, D.A. en
dc.contributor.author19 Thomas, K.K. en
dc.contributor.author20 Koole, O. en
dc.contributor.author21 Bershteyn, A. en
dc.contributor.author22 Ehrenkranz, P. en
dc.contributor.author23 Baeten, J.M. en
dc.contributor.author24 Celum, C. en


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