HSRC IR Repository

Implementing comprehensive prevention of mother-to-child transmission and HIV prevention for South African couples: study protocol for a randomized controlled trial

Show simple item record

dc.date.accessioned 2015-03-03 en
dc.date.accessioned 2016-12-04T13:54:21Z
dc.date.available 2016-12-04T13:54:21Z
dc.date.issued 2015-08-25 en
dc.identifier.uri http://hdl.handle.net/20.500.11910/2098
dc.description.abstract In rural South Africa, only two-thirds of HIV-positive pregnant women seeking antenatal care at community health centers took full advantage of 'prevention of mother-to-child transmission' (PMTCT) services in 2010. Studies generally support male involvement to promote PMTCT, but the nature and impact of that involvement is unclear and untested. Additionally, stigma, disclosure and intimate partner violence pose significant barriers to PMTCT uptake and retention in care, suggesting that male involvement may be `necessary, but not sufficient' to reduce infant HIV incidence. This study expands on a successful United States President's Emergency Plan for AIDS Relief (PEPFAR)-supported PMTCT couples intervention pilot study conducted in the Mpumalanga province, targeting HIV-positive pregnant women and their partners, the primary objective being to determine whether male partner involvement plus a behavioral intervention will significantly reduce infant HIV incidence. The study follows a cluster randomized controlled design enrolling two cohorts of HIV-positive pregnant women recruited from 12 randomly assigned Community Health Centers (CHC) (six experimental, six control). The two cohorts will consist of women attending without their male partners (n = 720) and women attending with their male partners (n = 720 couples), in order to determine whether the influence of male participation itself, or combined with a behavioral PMTCT intervention, can significantly reduce infant HIV infection ante-, peri- and postnatally. It is our intention to significantly increase PMTCT participation from current levels (69%) in the Mpumalanga province to between 90 and 95% through engaging women and couples in a controlled, six session ante- and postnatal risk-reducing and PMTCT promotion intervention addressing barriers to PMTCT (such as stigma, disclosure, intimate partner violence, communication, infant feeding practices and safer conception) that prevent women and men from utilizing treatment opportunities available to them and their infants. Based upon the encouraging preliminary results from our pilot study, successful CHC adoption of the program could have major public health policy implications for containing the epidemic among the most vulnerable populations in rural South Africa: HIV-positive pregnant women and their infants. en
dc.format.medium Print en
dc.subject PREVENTION OF MOTHER TO CHILD TRANSMISSION (PMTCT) PROGRAMME en
dc.subject HIV/AIDS en
dc.subject HEALTH en
dc.title Implementing comprehensive prevention of mother-to-child transmission and HIV prevention for South African couples: study protocol for a randomized controlled trial en
dc.type Journal Article en
dc.description.version Y en
dc.ProjectNumber N/A en
dc.Volume 15 en
dc.BudgetYear 2014/15 en
dc.ResearchGroup HIV/AIDS, STIs and TB en
dc.SourceTitle Trials en
dc.ArchiveNumber 8491 en
dc.PageNumber Online en
dc.outputnumber 7252 en
dc.bibliographictitle Jones, D., Peltzer, K., Weiss, S.M., Sifunda, S., Dwane, N., Ramlagan, S., Cook, R., Matseke, G., Maduna, V. & Spence, A. (2014) Implementing comprehensive prevention of mother-to-child transmission and HIV prevention for South African couples: study protocol for a randomized controlled trial. <i>Trials</i>. 15:Online. en
dc.publicationyear 2014 en
dc.contributor.author1 Jones, D. en
dc.contributor.author2 Peltzer, K. en
dc.contributor.author3 Weiss, S.M. en
dc.contributor.author4 Sifunda, S. en
dc.contributor.author5 Dwane, N. en
dc.contributor.author6 Ramlagan, S. en
dc.contributor.author7 Cook, R. en
dc.contributor.author8 Matseke, G. en
dc.contributor.author9 Maduna, V. en
dc.contributor.author10 Spence, A. en


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search HSRC IR


Browse

My Account