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Impact of on-site testing for maternal syphilis on treatment delays, treatment rates and perinatal mortality in rural South Africa: a randomised controlled trial

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dc.date.accessioned 2004-07-21 en
dc.date.accessioned 2020-02-20T10:44:58Z
dc.date.available 2020-02-20T10:44:58Z
dc.date.issued 2015-08-25 en
dc.identifier.uri http://hdl.handle.net/20.500.11910/7705
dc.description.abstract Syphilis remains a significant cause of preventable perinatal death in developing countries, with many women remaining untested and thus untreated. Syphilis testing in the clinic (on-site testing) may be a useful strategy to overcome this. We studied the impact of on-site syphilis testing on treatment delays and rates, and perinatal mortality. We conducted a cluster randomised controlled trial among seven pairs of primary healthcare clinics in rural South Africa, comparing on-site testing complemented by laboratory confirmation versus laboratory testing alone. Intervention clinics used the on-site test conducted by primary care nurses, with results and treatment available within an hour. Control clinics sent blood samples to the provincial laboratory, with results returned 2 weeks later. Of 7134 women seeking antenatal care with available test results, 793 (11.1%) tested positive for syphilis. Women at intervention clinics completed treatment 16 days sooner on average (95% confidence interval: 11 to 21), though there was no significant difference in the proportion receiving adequate treatment at intervention (64%) and control (69%) clinics. There was also no significant difference in the proportion experiencing perinatal loss (3.3% v 5.1%; adjusted risk difference: -0.9%; 95% CI -4.4 to 2.7). Despite reducing treatment delays, the addition of on-site syphilis testing to existing laboratory testing services did not lead to higher treatment rates or reduce perinatal mortality. However on-site testing for syphilis may remain an important option for improving antenatal care in settings where laboratory facilities are not available. en
dc.format.medium Print en
dc.subject SYPHILIS en
dc.subject WOMEN en
dc.subject RURAL COMMUNITIES en
dc.title Impact of on-site testing for maternal syphilis on treatment delays, treatment rates and perinatal mortality in rural South Africa: a randomised controlled trial en
dc.type Journal Article en
dc.description.version Y en
dc.Volume 79 en
dc.BudgetYear 2003/04 en
dc.ResearchGroup Surveys, Analyses, Modelling and Mapping en
dc.SourceTitle Sexually Transmitted Infections en
dc.ArchiveNumber 3105 en
dc.PageNumber 208-213 en
dc.outputnumber 1419 en
dc.bibliographictitle Myer, L., Wilkinson, D., Lombard, C., Zuma, K., Rotchford, K. & Adool Karim, S.S. (2003) Impact of on-site testing for maternal syphilis on treatment delays, treatment rates and perinatal mortality in rural South Africa: a randomised controlled trial. <i>Sexually Transmitted Infections</i>. 79:208-213. en
dc.publicationyear 2003 en
dc.contributor.author1 Myer, L. en
dc.contributor.author2 Wilkinson, D. en
dc.contributor.author3 Lombard, C. en
dc.contributor.author4 Zuma, K. en
dc.contributor.author5 Rotchford, K. en
dc.contributor.author6 Adool Karim, S.S. en


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