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Cohort profile: the Siyakhula cohort, rural South Africa

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dc.date.accessioned 2017-09-22 en
dc.date.accessioned 2021-11-24T17:15:30Z
dc.date.available 2021-11-24T17:15:30Z
dc.date.issued 2018-04-09 en
dc.identifier.uri http://hdl.handle.net/20.500.11910/11240
dc.description.abstract Each year millions of children in low- and middle-income countries (LMIC) fail to reach their developmental potential due to factors including poverty, malnutrition, poor stimulation and HIV. Although vertically-acquired HIV can now be prevented, little is known about the impact of HIV exposure in fetal and early life on the development of the many HIVnegative children. The Siyakhula Cohort was established within the Canadian Grand Challenges 'Saving Brains' initiative, to support re-enrolment of strategic cohorts in LMIC. This unique cohort in rural South Africa includes 1536 HIVnegative children born to HIV-infected (HIV-exposed) and HIV-uninfected (unexposed) mothers, enrolled from the Africa Health Research Institute (AHRI)(formerly the Africa Centre for Population Health (Africa Centre). The cohort includes data on HIV exposure in fetal and early life, and other early life factors (including breastfeeding) known to impact on later health outcomes. At birth, all children benefited from the early Prevention of Mother-to-Child-Transmission of HIV services in the district, and a subgroup were part of an additional early life breastfeeding intervention, the Vertical Transmission Study (VTS). This cohort pre-dated antiretroviral treatment (ART) roll-out, allowing for examination of outcomes associated with HIV exposure without ART exposure in utero and during breastfeeding. Current assessments at ages 7-11 years collected data on growth, health, cognition (including executive function), education and emotional-behavioural outcomes at primary school age. en
dc.format.medium Print en
dc.publisher Oxford University Press en
dc.subject HIV/AIDS en
dc.subject CHILD WELL-BEING en
dc.subject EARLY CHILDHOOD DEVELOPMENT (ECD) en
dc.subject SIYAKHULA COHORT en
dc.title Cohort profile: the Siyakhula cohort, rural South Africa en
dc.type Journal Article en
dc.ProjectNumber N/A en
dc.Volume 46(6) en
dc.BudgetYear 2017/18 en
dc.ResearchGroup Human and Social Development en
dc.SourceTitle International Journal of Epidemiology en
dc.ArchiveNumber 9981 en
dc.URL http://ktree.hsrc.ac.za/doc_read_all.php?docid=18876 en
dc.PageNumber Online en
dc.outputnumber 8892 en
dc.bibliographictitle Rochat, T.J., Houle, B., Stein, A., Pearson, R.M., Newell, M.L. & Bland, R.M. (2017) Cohort profile: the Siyakhula cohort, rural South Africa. <i>International Journal of Epidemiology</i>. September:Online. http://hdl.handle.net/20.500.11910/11240 en
dc.publicationyear 2017 en
dc.contributor.author1 Rochat, T.J. en
dc.contributor.author2 Houle, B. en
dc.contributor.author3 Stein, A. en
dc.contributor.author4 Pearson, R.M. en
dc.contributor.author5 Newell, M.L. en
dc.contributor.author6 Bland, R.M. en


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