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Maternal factors associated with infant neurodevelopment in HIV-exposed uninfected infants

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dc.date.accessioned 2020-02-14T10:15:31Z
dc.date.available 2020-02-14T10:15:31Z
dc.date.issued 2020-02-14 en
dc.identifier.uri http://hdl.handle.net/20.500.11910/15118
dc.description.abstract This study evaluated maternal factors associated with infant neurodevelopmental outcomes among HIV-exposed uninfected (HEU) infants in rural South Africa. This study followed pregnant women living with HIV pre- and postpartum and evaluated sociodemographic factors, use of antiretrovirals (ARVs), and mental health factors as predictors of HEU infant developmental outcomes (cognitive, receptive, and expressive communication, fine and gross motor skills). Participants were 80 mother infant dyads. Mothers were assessed during pregnancy, and HEU infant development was assessed at a mean (SD) of 13.36 (1.89) months of age. Women were an average (SD) of 28.9 (5.2) years of age, and infants were on average 13.4 (1.9) months old. An analysis of covariance indicated that infants whose mothers had ARV detected in dry blood spots at 32 weeks of pregnancy had lower functioning scores in the cognitive domain than those with undetected ARV (n = 14; M, 15.3 vs 17.2; P = .048). Antenatal physical intimate partner violence was also associated with delayed cognitive functioning (F (1, 74), 4.96; P = .029). This study found risks for delayed infant cognitive development to be associated with the use of ARV during pregnancy and intimate partner violence, although findings merit replication due to the low sample size. Given the growing number of HEU infants, the necessity to better understand the potential toxicity of ARV exposure in utero is apparent. Similarly, the need for preventing intimate partner violence and screening for, and managing, developmental delays among these infants is increasing. en
dc.format.medium Print en
dc.publisher Oxford University Press en
dc.subject PREGNANCY en
dc.subject HIV/AIDS en
dc.subject NEUROLOGY en
dc.title Maternal factors associated with infant neurodevelopment in HIV-exposed uninfected infants en
dc.type Journal Article en
dc.description.version Y en
dc.ProjectNumber PMAXAA en
dc.Volume January en
dc.BudgetYear 2019/20 en
dc.ResearchGroup Social Aspects of Public Health en
dc.SourceTitle Open Forum Infectious Diseases en
dc.PlaceOfPublication Oxford en
dc.ArchiveNumber 11172 en
dc.PageNumber Online en
dc.outputnumber 10287 en
dc.bibliographictitle Alcaide, M.L., Rodriguez, V.J., Abbamonte, J.M., Ramlagan, S., Sifunda, S., Weiss, S.M., Peltzer, K. & Jones, D.L. (2020) Maternal factors associated with infant neurodevelopment in HIV-exposed uninfected infants. <i>Open Forum Infectious Diseases</i>. January:Online. en
dc.publicationyear 2020 en
dc.contributor.author1 Alcaide, M.L. en
dc.contributor.author2 Rodriguez, V.J. en
dc.contributor.author3 Abbamonte, J.M. en
dc.contributor.author4 Ramlagan, S. en
dc.contributor.author5 Sifunda, S. en
dc.contributor.author6 Weiss, S.M. en
dc.contributor.author7 Peltzer, K. en
dc.contributor.author8 Jones, D.L. en

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