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Predictors of suboptimal adherence to isoniazid preventive therapy among adolescents and children living with HIV

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dc.date.accessioned 2021-03-30T08:15:05Z
dc.date.available 2021-03-30T08:15:05Z
dc.date.issued 2021-03-30 en
dc.identifier.uri http://hdl.handle.net/20.500.11910/15932
dc.description.abstract This study identified factors associated with adherence to a 6-month isoniazid preventive therapy (IPT) course among adolescents and children living with HIV. Forty adolescents living with HIV and 48 primary caregivers of children living with HIV completed a Likert-based survey to measure respondent opinions regarding access to care, quality of care, preferred regimens, perceived stigma, and confidence in self-efficacy. Sociodemographic data were collected and adherence measured as the average of pill counts obtained while on IPT. The rates of suboptimal adherence (< 95% adherent) were 22.5% among adolescents and 37.5% among the children of primary caregivers. Univariate logistic regression was used to model the change in the odds of suboptimal adherence. Independent factors associated with suboptimal adherence among adolescents included age, education level, the cost of coming to clinic, stigma from community members, and two variables relating to self-efficacy. Among primary caregivers, child age, concerns about stigma, and location preference for meeting a community-health worker were associated with suboptimal adherence. To determine whether these combined factors contributed different information to the prediction of suboptimal adherence, a risk score containing these predictors was constructed for each group. The risk score had an AUC of 0.87 (95% CI: 0.76, 0.99) among adolescents and an AUC of 0.76 (95% CI: 0.62, 0.90), among primary caregivers suggesting that these variables may have complementary predictive utility. The heterogeneous scope and associations of these variables in different populations suggests that interventions aiming to increase optimal adherence will need to be tailored to specific populations and multifaceted in nature. Ideally interventions should address both long-established barriers to adherence such as cost of transportation to attend clinic and more nuanced psychosocial barriers such as perceived community stigma and confidence in self-efficacy. en
dc.format.medium Print en
dc.publisher Public Library Science en
dc.subject CHILDREN en
dc.subject HIV/AIDS en
dc.subject ADOLESCENTS en
dc.subject TUBERCULOSIS en
dc.title Predictors of suboptimal adherence to isoniazid preventive therapy among adolescents and children living with HIV en
dc.type Journal Article en
dc.description.version Y en
dc.ProjectNumber N/A en
dc.Volume March en
dc.BudgetYear 2020/21 en
dc.ResearchGroup Human and Social Capabilities en
dc.SourceTitle PLoS One en
dc.ArchiveNumber 11907 en
dc.PageNumber Online en
dc.outputnumber 11052 en
dc.bibliographictitle Kay, A.W., Thivalapill , N., Skinner, D., Dube, G.S., Dlamini, N., Mzileni, B., Fuentes, P., Ustero, P., Adams, L.V. & Mandalakas, A.M. (2020) Predictors of suboptimal adherence to isoniazid preventive therapy among adolescents and children living with HIV. <i>PLoS One</i>. March:Online. en
dc.publicationyear 2020 en
dc.contributor.author1 Kay, A.W. en
dc.contributor.author2 Thivalapill , N. en
dc.contributor.author3 Skinner, D. en
dc.contributor.author4 Dube, G.S. en
dc.contributor.author5 Dlamini, N. en
dc.contributor.author6 Mzileni, B. en
dc.contributor.author7 Fuentes, P. en
dc.contributor.author8 Ustero, P. en
dc.contributor.author9 Adams, L.V. en
dc.contributor.author10 Mandalakas, A.M. en


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