Parental childhood growth and offspring birthweight: pooled analyses from four birth cohorts in low and middle income countries

Show simple item record 2015-03-17 en 2022-08-17T16:37:08Z 2022-08-17T16:37:08Z 2015-08-25 en
dc.description.abstract Associations between parental and offspring size at birth are well established, but the relative importance of parental growth at different ages as predictors of offspring birthweight is less certain. Here we model parental birthweight and postnatal conditional growth in specific age periods as predictors of offspring birthweight. We analyzed data from 3,392 adults participating in four prospective birth cohorts and 5,506 of their offspring. There was no significant heterogeneity by study site or offspring sex. 1SD increase in maternal birthweight was associated with offspring birthweight increases of 102 g, 1SD in maternal length growth 0-2 year with 46 g, and 1SD in maternal height growth Mid-childhood (MC)-adulthood with 27 g. Maternal relative weight measures were associated with 24 g offspring birth weight increases (2 year- MC) and 49 g for MC-adulthood period but not with earlier relative weight 0-2 year. For fathers, birthweight, and linear/length growth from 0-2 year were associated with increases of 57 and 56 g in offspring birthweight, respectively but not thereafter. Maternal and paternal birthweight and growth from birth to 2 year each predict offspring birthweight. Maternal growth from MC-adulthood, relative weight from 2-MC and MC-adulthood also predict offspring birthweight. These findings suggest that shared genes and/or adequate nutrition during early life for both parents may confer benefits to the next generation, and highlight the importance of maternal height and weight prior to conception. The stronger matrilineal than patrilineal relationships with offspring birth weight are consistent with the hypothesis that improving the early growth conditions of young females can improve birth outcomes in the next generation. en
dc.format.medium Print en
dc.subject CHILD WELL-BEING en
dc.subject BIRTHWEIGHT en
dc.title Parental childhood growth and offspring birthweight: pooled analyses from four birth cohorts in low and middle income countries en
dc.type Journal Article en
dc.description.version Y en
dc.ProjectNumber N/A en
dc.Volume 27 en
dc.BudgetYear 2014/15 en
dc.ResearchGroup HIV/AIDS, STIs and TB en
dc.ResearchGroup Human and Social Development en
dc.SourceTitle American Journal of Human Biology en
dc.ArchiveNumber 8546 en
dc.URL en
dc.PageNumber 99-105 en
dc.outputnumber 7314 en
dc.bibliographictitle Addo, O.Y., Stein, A.D., Fall, C.H.D., Gigante, D.P., Guntupalli, A.M., Horta, B.L., Kuzawa, C.W., Lee, N., Norris, S.A., Osmond, C., Prabhakaran, P., Richter, L.M., Sachdev, H.P.S. & Martorell, R. (2015) Parental childhood growth and offspring birthweight: pooled analyses from four birth cohorts in low and middle income countries. American Journal of Human Biology. 27:99-105. en
dc.publicationyear 2015 en
dc.contributor.author1 Addo, O.Y. en
dc.contributor.author2 Stein, A.D. en
dc.contributor.author3 Fall, C.H.D. en
dc.contributor.author4 Gigante, D.P. en
dc.contributor.author5 Guntupalli, A.M. en
dc.contributor.author6 Horta, B.L. en
dc.contributor.author7 Kuzawa, C.W. en
dc.contributor.author8 Lee, N. en
dc.contributor.author9 Norris, S.A. en
dc.contributor.author10 Osmond, C. en
dc.contributor.author11 Prabhakaran, P. en
dc.contributor.author12 Richter, L.M. en
dc.contributor.author13 Sachdev, H.P.S. en
dc.contributor.author14 Martorell, R. en

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