Time to ART initiation among patients treated for Rafampicin-resistant tuberculosis in Khayelitsha, South Africa: impact on mortality and treatment success

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dc.date.accessioned	2015-11-20	en
dc.date.accessioned	2023-07-29T01:03:39Z
dc.date.available	2023-07-29T01:03:39Z
dc.date.issued	2023-07-28	en
dc.identifier.uri	http://hdl.handle.net/20.500.11910/21862
dc.description.abstract	Khayelitsha, South Africa, with high burdens of rifampicin-resistant tuberculosis (RR-TB) and HIV co-infection. The objective of this study was to describe time to antiretroviral treatment (ART) initiation among HIV-infected RR-TB patients initiating RR-TB treatment and to assess the association between time to ART initiation and treatment outcomes. A retrospective cohort study of patients with RR-TB and HIV co-infection not on ART at RRTB treatment initiation. Despite wide variation in time to ART initiation among RR-TB patients, no differences in mortality or treatment success were observed. However, a significant proportion of patients did not initiate ART despite receiving >4 months of RR-TB treatment. Programmatic priorities should focus on ensuring all patients with RR-TB/HIV co-infection initiate ART regardless of CD4 count, with special attention for patients with CD4 counts 100 to initiate ART as soon as possible after RR-TB treatment initiation.	en
dc.format.medium	Print	en
dc.publisher	Public Library Science	en
dc.subject	TUBERCULOSIS	en
dc.subject	KHAYELITSHA	en
dc.subject	TREATMENT CENTRES	en
dc.subject	ANTIRETROVIRAL THERAPY (ART)	en
dc.title	Time to ART initiation among patients treated for Rafampicin-resistant tuberculosis in Khayelitsha, South Africa: impact on mortality and treatment success	en
dc.type	Journal Article	en
dc.description.version	Y	en
dc.ProjectNumber	N/A	en
dc.Volume	10(11)	en
dc.BudgetYear	2015/16	en
dc.ResearchGroup	HIV/AIDS, STIs and TB	en
dc.SourceTitle	PLoS One	en
dc.PlaceOfPublication	San Francisco, USA	en
dc.ArchiveNumber	8876	en
dc.URL	http://ktree.hsrc.ac.za/doc_read_all.php?docid=15844	en
dc.PageNumber	Online	en
dc.outputnumber	7650	en
dc.bibliographictitle	Daniels, J.F., Khogali, M., Mohr, E., Cox, V., Moyo, S., Edginton, M., Hinderaker, S.G., Meintjes, G., Hughes, J., De Azevedo, V., Van Cutsem, G. & Cox, H.S. (2015) Time to ART initiation among patients treated for Rafampicin-resistant tuberculosis in Khayelitsha, South Africa: impact on mortality and treatment success. PLoS One. 10(11):Online.	en
dc.publicationyear	2015	en
dc.contributor.author1	Daniels, J.F.	en
dc.contributor.author2	Khogali, M.	en
dc.contributor.author3	Mohr, E.	en
dc.contributor.author4	Cox, V.	en
dc.contributor.author5	Moyo, S.	en
dc.contributor.author6	Edginton, M.	en
dc.contributor.author7	Hinderaker, S.G.	en
dc.contributor.author8	Meintjes, G.	en
dc.contributor.author9	Hughes, J.	en
dc.contributor.author10	De Azevedo, V.	en
dc.contributor.author11	Van Cutsem, G.	en
dc.contributor.author12	Cox, H.S.	en