Time to ART initiation among patients treated for Rafampicin-resistant tuberculosis in Khayelitsha, South Africa: impact on mortality and treatment success

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dc.date.accessioned 2015-11-20 en
dc.date.accessioned 2025-11-17T22:49:25Z
dc.date.available 2025-11-17T22:49:25Z
dc.date.issued 2023-07-28 en
dc.identifier.uri http://hdl.handle.net/20.500.11910/21862
dc.description.abstract Khayelitsha, South Africa, with high burdens of rifampicin-resistant tuberculosis (RR-TB) and HIV co-infection. The objective of this study was to describe time to antiretroviral treatment (ART) initiation among HIV-infected RR-TB patients initiating RR-TB treatment and to assess the association between time to ART initiation and treatment outcomes. A retrospective cohort study of patients with RR-TB and HIV co-infection not on ART at RRTB treatment initiation. Despite wide variation in time to ART initiation among RR-TB patients, no differences in mortality or treatment success were observed. However, a significant proportion of patients did not initiate ART despite receiving >4 months of RR-TB treatment. Programmatic priorities should focus on ensuring all patients with RR-TB/HIV co-infection initiate ART regardless of CD4 count, with special attention for patients with CD4 counts 100 to initiate ART as soon as possible after RR-TB treatment initiation. en
dc.format.medium Print en
dc.publisher Public Library Science en
dc.subject TUBERCULOSIS en
dc.subject KHAYELITSHA en
dc.subject TREATMENT CENTRES en
dc.subject ANTIRETROVIRAL THERAPY (ART) en
dc.title Time to ART initiation among patients treated for Rafampicin-resistant tuberculosis in Khayelitsha, South Africa: impact on mortality and treatment success en
dc.type Journal Articles en
dc.description.version Y en
dc.ProjectNumber N/A en
dc.Volume 10(11) en
dc.BudgetYear 2015/16 en
dc.ResearchGroup HIV/AIDS, STIs and TB en
dc.SourceTitle PLoS One en
dc.PlaceOfPublication San Francisco, USA en
dc.ArchiveNumber 8876 en
dc.PageNumber Online en
dc.outputnumber 7650 en
dc.bibliographictitle Daniels, J.F., Khogali, M., Mohr, E., Cox, V., Moyo, S., Edginton, M., Hinderaker, S.G., Meintjes, G., Hughes, J., De Azevedo, V., Van Cutsem, G. & Cox, H.S. (2015) Time to ART initiation among patients treated for Rafampicin-resistant tuberculosis in Khayelitsha, South Africa: impact on mortality and treatment success. PLoS One. 10(11):Online. http://hdl.handle.net/20.500.11910/21862 http://hdl.handle.net/20.500.11910/21862 en
dc.publicationyear 2015 en
dc.contributor.author1 Daniels, J.F. en
dc.contributor.author2 Khogali, M. en
dc.contributor.author3 Mohr, E. en
dc.contributor.author4 Cox, V. en
dc.contributor.author5 Moyo, S. en
dc.contributor.author6 Edginton, M. en
dc.contributor.author7 Hinderaker, S.G. en
dc.contributor.author8 Meintjes, G. en
dc.contributor.author9 Hughes, J. en
dc.contributor.author10 De Azevedo, V. en
dc.contributor.author11 Van Cutsem, G. en
dc.contributor.author12 Cox, H.S. en


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