Can deworming delay immunosuppression in HIV?

Show simple item record 2012-12-03 en 2022-08-17T18:03:41Z 2022-08-17T18:03:41Z 2015-08-25 en
dc.description.abstract In sub-Saharan Africa, co-infection with HIV-1 and helminths is very common, affecting the natural history and disease progression of both. However, the effects of interaction between the two infections are a contentious issue. Findings from various studies have shown impaired immune responses against HIV in individuals with helminth infections, suggesting a role for helminths in immunity attenuation, HIV pathogenesis, and accelerated disease progression. However, the complex interplay between the two infections in people living in poverty hampers identification of a causal relation. The association is beset with confounding factors that complicate the design of studies to define the effects of helminth infections on HIV disease progression. These factors include the bidirectional interaction between the two infections, the eff ects of other bacterial and viral infectious agents, malnutrition, and possible different immunological effects of different helminth species alone and in combination. en
dc.format.medium Print en
dc.subject HIV/AIDS en
dc.subject SUB-SAHARAN AFRICA en
dc.title Can deworming delay immunosuppression in HIV? en
dc.type Journal Article en
dc.description.version Y en
dc.ProjectNumber N/A en
dc.Volume 12 en
dc.BudgetYear 2012/13 en
dc.ResearchGroup HIV/AIDS, STIs and TB en
dc.SourceTitle The Lancet en
dc.ArchiveNumber 7471 en
dc.PageNumber 899-900 en
dc.outputnumber 6121 en
dc.bibliographictitle Mkhize-Kwitshana, Z.L. & Mabaso, M.H.L. (2012) Can deworming delay immunosuppression in HIV?. The Lancet. 12:899-900. en
dc.publicationyear 2012 en
dc.contributor.author1 Mkhize-Kwitshana, Z.L. en
dc.contributor.author2 Mabaso, M.H.L. en

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