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dc.date.accessioned | 2012-09-11 | en |
dc.date.accessioned | 2022-08-17T18:10:09Z | |
dc.date.available | 2022-08-17T18:10:09Z | |
dc.date.issued | 2015-08-25 | en |
dc.identifier.uri | http://hdl.handle.net/20.500.11910/3291 | |
dc.description.abstract | To estimate ART adherence rates during pregnancy and postpartum in high-, middle- and low-income countries. MEDLINE, EMBASE, SCI Web of Science, NLM Gateway and Google scholar databases were searched. We included all studies reporting adherence rates as a primary or secondary outcome among HIV-infected pregnant women. Two independent reviewers extracted data on adherence and study characteristics. A random-effects model was used to pool adherence rates; sensitivity, heterogeneity, and publication bias were assessed. Of 72 eligible articles, 51studies involving 20,153 HIV-infected pregnant women were included. Most studies were from United States (n=14, 27%) followed by Kenya (n=6, 12%), South Africa (n=5, 10%), and Zambia (n=5, 10%). The threshold defining good adherence to ART varied across studies (>80%, >90%, >95%, 100%). The pooled proportion of women with adequate adherence levels was higher during the antepartum (75.7%, 95% CI 71.5-79.7%) than during postpartum (53.0%, 95% 32.8% to 72.7%) (p=0.005). Selected reported barriers for non-adherence included physical, economic and emotional stresses, depression (especially post-delivery), alcohol or drug use, and ART dosing frequency or pill burden. Our findings indicate that only 73.5% of pregnant women achieved optimal ART adherence. Reaching adequate ART adherence levels was a challenge in pregnancy, but especially during the postpartum period. Further research to investigate specific barriers and interventions to address them are urgently needed globally. | en |
dc.format.medium | en | |
dc.subject | PREGNANCY | en |
dc.subject | ANTIRETROVIRAL THERAPY | en |
dc.subject | HIV/AIDS | en |
dc.title | Adherence to antiretroviral therapy during and after pregnancy in low-, middle and high income countries: a systematic review and meta-analysis | en |
dc.type | Journal Article | en |
dc.description.version | Y | en |
dc.ProjectNumber | N/A | en |
dc.Volume | August | en |
dc.BudgetYear | 2012/13 | en |
dc.ResearchGroup | HIV/AIDS, STIs and TB | en |
dc.SourceTitle | AIDS | en |
dc.ArchiveNumber | 7388 | en |
dc.PageNumber | Online | en |
dc.outputnumber | 6039 | en |
dc.bibliographictitle | Nachega, J.B., Uthman, O.A., Anderson, J., Peltzer, K., Wampold, S., Cotton, M.F., Mills, E.J., Ho, Y.S., Stringer, J.S.A., McIntyre, J.A. & Mofenson, L.M. (2012) Adherence to antiretroviral therapy during and after pregnancy in low-, middle and high income countries: a systematic review and meta-analysis. AIDS. August:Online. http://hdl.handle.net/20.500.11910/3291 | en |
dc.publicationyear | 2012 | en |
dc.contributor.author1 | Nachega, J.B. | en |
dc.contributor.author2 | Uthman, O.A. | en |
dc.contributor.author3 | Anderson, J. | en |
dc.contributor.author4 | Peltzer, K. | en |
dc.contributor.author5 | Wampold, S. | en |
dc.contributor.author6 | Cotton, M.F. | en |
dc.contributor.author7 | Mills, E.J. | en |
dc.contributor.author8 | Ho, Y.S. | en |
dc.contributor.author9 | Stringer, J.S.A. | en |
dc.contributor.author10 | McIntyre, J.A. | en |
dc.contributor.author11 | Mofenson, L.M. | en |
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