Size at birth, weight gain in infancy and childhood, and adult diabetes risk in five low- or middle-income country birth cohorts

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dc.date.accessioned 2012-03-29 en
dc.date.accessioned 2022-08-17T18:24:29Z
dc.date.available 2022-08-17T18:24:29Z
dc.date.issued 2015-08-25 en
dc.identifier.uri http://hdl.handle.net/20.500.11910/3474
dc.description.abstract We examined associations of birth weight and weight gain in infancy and early childhood with type 2 diabetes (DM) risk in five cohorts from low- and middle-income countries. Participants were 6,511 young adults from Brazil, Guatemala, India, the Philippines, and South Africa. Exposures were weight at birth, at 24 and 48 months, and adult weight, and conditional weight gain (CWG, deviation from expected weight gain) between these ages. Outcomes were adult fasting glucose, impaired fasting glucose or DM (IFG/DM), and insulin resistance homeostasis model assessment (IR-HOMA, three cohorts). Birth weight was inversely associated with adult glucose and risk of IFG/DM (odds ratio 0.91[95% CI 0.84-0.99] per SD). Weight at 24 and 48 months and CWG 0-24 and 24-48 months were unrelated to glucose and IFG/DM; however, CWG 48 months-adulthood was positively related to IFG/DM (1.32 [1.22-1.43] per SD). After adjusting for adult waist circumference, birth weight, weight at 24 and 48 months and CWG 0-24 months were inversely associated with glucose and IFG/DM. Birth weight was unrelated to IR-HOMA, whereas greater CWG at 0-24 and 24-48 months and 48 months-adulthood predicted higher IR-HOMA (all P < 0.001). After adjusting for adult waist circumference, birth weight was inversely related to IR-HOMA. Lower birth weight and accelerated weight gain after 48 months are risk factors for adult glucose intolerance. Accelerated weight gain between 0 and 24 months did not predict glucose intolerance but did predict higher insulin resistance. en
dc.format.medium Print en
dc.subject CHILDREN en
dc.subject BIRTH TO TEN NOW BIRTH TO TWENTY (BT20) en
dc.subject WEIGHT MANAGEMENT en
dc.subject NUTRITION en
dc.subject INFANT MORTALITY en
dc.title Size at birth, weight gain in infancy and childhood, and adult diabetes risk in five low- or middle-income country birth cohorts en
dc.type Journal Article en
dc.description.version Y en
dc.Volume 35 en
dc.BudgetYear 2011/12 en
dc.ResearchGroup HIV/AIDS, STIs and TB en
dc.SourceTitle Diabetes Care en
dc.ArchiveNumber 7206 en
dc.PageNumber 72-79 en
dc.outputnumber 5853 en
dc.bibliographictitle Norris, S.A., Osmond, C., Gigante, D., Kuzawa, C.W., Ramakrishnan, L., Lee, N.R., Ramirez-Zea, M., Richter, L.M., Stein, A.D., Tandon, N., Fall, C.H.D. & COHORTS Group, (2012) Size at birth, weight gain in infancy and childhood, and adult diabetes risk in five low- or middle-income country birth cohorts. Diabetes Care. 35:72-79. http://hdl.handle.net/20.500.11910/3474 en
dc.publicationyear 2012 en
dc.contributor.author1 Norris, S.A. en
dc.contributor.author2 Osmond, C. en
dc.contributor.author3 Gigante, D. en
dc.contributor.author4 Kuzawa, C.W. en
dc.contributor.author5 Ramakrishnan, L. en
dc.contributor.author6 Lee, N.R. en
dc.contributor.author7 Ramirez-Zea, M. en
dc.contributor.author8 Richter, L.M. en
dc.contributor.author9 Stein, A.D. en
dc.contributor.author10 Tandon, N. en
dc.contributor.author11 Fall, C.H.D. en
dc.contributor.author12 COHORTS Group, en


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