Self-report and dry blood spot measurement of antiretroviral medications as markers of adherence in pregnant women in rural South Africa

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Alcaide, M.L., Ramlagan, S., Rodriquez, V.J., Cook, R., Peltzer, K., Weiss, S.M., Sifunda, S. & Jones, D.L. (2017) Self-report and dry blood spot measurement of antiretroviral medications as markers of adherence in pregnant women in rural South Africa. AIDS and Behavior. 21(7):2135-2140. http://hdl.handle.net/20.500.11910/10890

http://hdl.handle.net/20.500.11910/10890
 
Abstract:
Antiretroviral (ARV) adherence is essential to prevent mother-to-child transmission of HIV. This study compared self-reported adherence versus ARV detection in dried blood spots (DBS) among N = 392 HIV-infected pregnantwomen in SouthAfrica (SA).Women completed two self-reported adherence measures [visual analog scale (VAS), AIDS Clinical Trials Group Adherence (ACTG)]. Adherence was 89% (VAS), 80% (ACTG), and 74% (DBS). Self-report measuresmarginally agreed withDBS(VAS:Kappa = 0.101, Area under the ROC curve (AUROC) = 0.543; ACTG: Kappa = 0.081,AUROC = 0.538). Self-reported adherence was overestimated and agreement with DBS was poor. Validation of self-reportedARVadherence among pregnant HIV women in SA is needed.
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04 Apr 2017
 
HIV/AIDS
ANTIRETROVIRAL THERAPY
RURAL COMMUNITIES
PREGNANCY
 
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