Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid

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Cilliers, K., Labadarios, D., Schaaf, H.S., Willemse, M., Maritz, J.S., Werely, C.J., Hussey, G. & Donald, P.R. (2010) Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid. Acta Paediatrica. 99(5):705-710. http://hdl.handle.net/20.500.11910/3945 http://hdl.handle.net/20.500.11910/3945

http://hdl.handle.net/20.500.11910/3945
 
Abstract:
Aim: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5'-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, receiving INH regimens. Methods: Children from the Western Cape of South Africa hospitalized for tuberculosis (TB) management were studied. Plasma PLP concentrations were determined on enrolment, 1-month after commencing TB treatment, and again after 4-month's treatment. The children received a supplement meeting pyridoxine requirements. Conclusion: Plasma PLP concentrations in children treated for TB were low on enrolment in HIV-infected and HIV-uninfected children; after 4-month's treatment low values were still common in HIV-infected children. Additional pyridoxine supplementation of malnourished children treated for tuberculosis is advisable, particularly those HIV-infected.
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25 Aug 2015
 
HIV/AIDS
CHILDREN
TUBERCULOSIS
TREATMENT CENTRES
 
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