Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid

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dc.date.accessioned 2011-02-08 en
dc.date.accessioned 2023-07-24T16:01:29Z
dc.date.available 2023-07-24T16:01:29Z
dc.date.issued 2015-08-25 en
dc.identifier.uri http://hdl.handle.net/20.500.11910/3945
dc.description.abstract Aim: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5'-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, receiving INH regimens. Methods: Children from the Western Cape of South Africa hospitalized for tuberculosis (TB) management were studied. Plasma PLP concentrations were determined on enrolment, 1-month after commencing TB treatment, and again after 4-month's treatment. The children received a supplement meeting pyridoxine requirements. Conclusion: Plasma PLP concentrations in children treated for TB were low on enrolment in HIV-infected and HIV-uninfected children; after 4-month's treatment low values were still common in HIV-infected children. Additional pyridoxine supplementation of malnourished children treated for tuberculosis is advisable, particularly those HIV-infected. en
dc.format.medium Print en
dc.subject HIV/AIDS en
dc.subject CHILDREN en
dc.subject TUBERCULOSIS en
dc.subject TREATMENT CENTRES en
dc.title Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid en
dc.type Journal Article en
dc.description.version Y en
dc.ProjectNumber N/A en
dc.Volume 99(5) en
dc.BudgetYear 2010/11 en
dc.ResearchGroup Population Health, Health Systems and Innovation en
dc.SourceTitle Acta Paediatrica en
dc.ArchiveNumber 6669 en
dc.PageNumber 705-710 en
dc.outputnumber 5320 en
dc.bibliographictitle Cilliers, K., Labadarios, D., Schaaf, H.S., Willemse, M., Maritz, J.S., Werely, C.J., Hussey, G. & Donald, P.R. (2010) Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid. Acta Paediatrica. 99(5):705-710. http://hdl.handle.net/20.500.11910/3945 http://hdl.handle.net/20.500.11910/3945 en
dc.publicationyear 2010 en
dc.contributor.author1 Cilliers, K. en
dc.contributor.author2 Labadarios, D. en
dc.contributor.author3 Schaaf, H.S. en
dc.contributor.author4 Willemse, M. en
dc.contributor.author5 Maritz, J.S. en
dc.contributor.author6 Werely, C.J. en
dc.contributor.author7 Hussey, G. en
dc.contributor.author8 Donald, P.R. en


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